Heme Oxygenase-1 as a Potential Therapeutic Target for Hepatoprotection
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چکیده
منابع مشابه
Heme oxygenase-1 as a potential therapeutic target for hepatoprotection.
Heme oxygenase (HO), the rate limiting enzyme in the breakdown of heme into carbon monoxide (CO), iron and bilirubin, has recently received overwhelming research attention. To date three mammalian HO isozymes have been identified, and the only inducible form is HO-1 while HO-2 and HO-3 are constitutively expressed. Advances in unveiling signal transduction network indicate that a battery of red...
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The heme oxygenase (HO) system has received significant attention in recent years as a possible novel target for antihypertensive therapy. HO is the rate limiting enzyme in the metabolism of heme releasing bioactive molecules carbon monoxide (CO) and bilirubin each with beneficial cardiovascular actions. Induction of HO-1 has been demonstrated to lower blood pressure in several animal models of...
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Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in the catabolism of heme, followed by production of biliverdin, free iron and carbon monoxide (CO). HO-1 is a stress-responsive protein induced by various oxidative agents. Recent studies demonstrate that the expression of HO-1 in response to different inflammatory mediators may contribute to the resolution of inflammation and has protective ...
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Lipopolysaccharide (LPS) causes hepatic injury that is mediated, in part, by upregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Ketamine has been shown to prevent these effects. Because upregulation of heme oxygenase-1 (HO-1) has hepatoprotective effects, as does carbon monoxide (CO), an end product of the HO-1 catalytic reaction, we examined the effects of HO-...
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Heme oxygenase-1 (HO1) degrades heme to carbon monoxide (CO), biliverdin, and ferrous iron. Through these products, HO1 mitigates cellular injury by exerting anti-oxidant, anti-apoptotic, and anti-inflammatory effects. Several lines of evidence indicate that angiogenic factors, such as vascular endothelial growth factor A (VEGF) and stromal cell-derived factor 1 (SDF1), mediate their proangioge...
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ژورنال
عنوان ژورنال: BMB Reports
سال: 2006
ISSN: 1976-6696
DOI: 10.5483/bmbrep.2006.39.5.479